A business's turf on the Internet. In the early years of the Web (circa 1995), businesses that got online, established a Web site, and built an online community were said to be "staking out real estate" in cyberspace, in hopes of gaining first-mover advantage. Real estate also refers to the available space on a Web page for online ads.
For example, "They're not sure if they want to host buttons as well as ad banners. They're afraid that would mean sacrificing too much real estate on their homepage."